Tomasz Ciach PhD Eng. Professor
 
Beata Butruk-Raszeja PhD Eng.
 
Magdalena Janczewska MSc Eng.
 
Katarzyna Każmierska MSc Eng.
Kamil Kopeć MSc Eng.
 
Piotr Kowalczyk MSc Eng.
 
Martyna Kucharska PhD Eng.
 
Aleksandra Kuźmińska, MSc Eng.
 
Aleksandra Kulikowska MSc Eng.
 
Ilona Łojszczyk MSc Eng.
 
Aleksandra Mościcka-Studzińska MSc Eng.
 
Rafał Podgórski MSc Eng.
 
Aleksandra Poniatowska MSc Eng.
 
Agata Stefanek MSc Eng.
 
Paulina Trzaskowska MSc Eng.
 
Maciej Trzaskowski MSc Eng.
 

Iga Wasiak MSc Eng.

 
Michał Wojasiński MSc Eng.
 

 

Home arrow Projects arrow Coatings for medical use arrow Hemocompatible biopasive surfaces
Hemocompatible biopasive surfaces

The have developed method coating polyurethanes with hydrogel layers. The modification is based on free radical polymerization. A suitable reagent system allowed to produce free radicals only at the interface of the base polymer / polymer modifier. This procedure strongly improved efficiency of the reaction and allowed to avoid homopolymerization in a solution of the polymer modifier. The resulting free radicals in the system "bind" the modifying polymer chains, resulting in a highly crosslinked structure - the hydrogel.

The coating has physicochemical properties similar to those of the extracellular matrix and it is characterized by high biocompatibility. The surface layer of hydrogel is able to absorb water with a volume several times larger than the volume of the starting material. The high hydrophilicity of the surface results in a significant reduction in thrombogenicity of the material. Experiments with whole blood yielded very good results - showed a significant decrease in the number of adhered and activated platelets as compared to the unmodified material (Figure 2).

Fig.1: Structure of liophilized hydrogel coating.

Fig.2: Coating of polyurethane with hydrogel layer strongly improved hemocompatibility of the material.

 

 

Contact person:

Beata Butruk (e-mail)

More info:

Papers available on ResearchGate.

 

 

 

 
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