Tomasz Ciach PhD Eng. Professor
 
Beata Butruk-Raszeja PhD Eng.
 
Magdalena Janczewska MSc Eng.
 
Katarzyna Każmierska MSc Eng.
Kamil Kopeć MSc Eng.
 
Piotr Kowalczyk MSc Eng.
 
Martyna Kucharska PhD Eng.
 
Aleksandra Kuźmińska, MSc Eng.
 
Aleksandra Kulikowska MSc Eng.
 
Ilona Łojszczyk MSc Eng.
 
Aleksandra Mościcka-Studzińska MSc Eng.
 
Rafał Podgórski MSc Eng.
 
Aleksandra Poniatowska MSc Eng.
 
Agata Stefanek MSc Eng.
 
Paulina Trzaskowska MSc Eng.
 
Maciej Trzaskowski MSc Eng.
 

Iga Wasiak MSc Eng.

 
Michał Wojasiński MSc Eng.
 

 

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Who are we

BioMedical Engineering Laboratory was established in 2002 on the Faculty of Chemical and Process Engineering, Warsaw University of Technology. The aim was to apply the knowledge and methods of Chemical Engineering in the field of medicine and pharmacy: innovative drug release systems, less invasive medical devices and regenerative medicine. It is also a place for students - young scientist, to work on their master and doctorate research and to encourage them to their own scientific investigations.

 

From the very beginning scientific investigations were focused on practical application what resulted in the development of drug eluting coating for coronary stent which was implemented in the industry. Coating was based on the biodegradable polymer and an anti proliferative drug. After successful animal tests performed on pigs, and human trials, coated stent was introduced to the market in 2005. As compared to the existing solution this drug eluting stent appears to be safer in the light of MACE (Major Cardiac Event) coefficient. Another area on investigation was biocompatible coatings for medical devices. The new method and apparatus for the measurement of friction coefficient of urinary catheters against pig urinary track (ex vivo) was invented and build. This device helped us to develop a low friction – low pain coating for urinary catheters. A new type of coated urinary catheters was tested in the hospital and has got a very good opinion of both patients and doctors. Coated catheters have also showed much lower probability of bacterial infection, as compared to uncoated one. This type of coated catheters have also been tested against infection of typical, hospital related urinary track pathogen Proteus Mirabilis, in the Bristol Urological Institute, leading European institution in urinary catheters testing, and has got good opinion. To improve even further the antibacterial properties of catheters they have been impregnated with antibacterial agent which is slowly released to the bladder environment. Developed technology has been introduced to the company and since 2008 coated catheters are manufactured in Poland.

 

Currently the main areas of research performed in the BioMedical Laboratory are as follows:
1. Micro and nano particles for drug delivery, including targeted drug delivery for tumor chemotherapy and externally trigger able drug eluting particles.
2. Advanced electronic drug delivery implants which can be implanted inside a human mouth or completely inside a body. Implants are designed to release drugs for chronic disease treatment, and to constantly determine health situation of the patient. This research also includes work on iontophoretic drug delivery through human tissue and special membranes which works as a valve for drug delivery.
3. Biodegradable bone implants of three types. Solid bone implants for heavy loaded bones, which have to degrade slowly, to have high initial compression strength and to release signaling proteins to promote remodeling of the implant into the natural bone. Second type is a soft spongy bone implants which can be easily trim by the surgeon to the desired complex shape, for jaw and cranium bones. The last type is an injectable system to be applied in filling of cavities left after bone tumor removal, when the entrance hole is small compared to large volume inside a bone. All the bone implants are able to release certain drugs or proteins.
4. Biodegradable hydrogel sealing for PET fabric based vane grafts – artificial vanes. This new type of biopolymer is polysaccharide based material which prevents cloth formation, and slowly degrades being replaced by the tissue. Coating is able to release certain antibiotics to decrease a risk of infection after implantation.
5. Bioactive coatings for long term implants and medical devices, like catheters, vane and heart prosthesis. Coatings should be resistant to oxidative properties of blood and to hydrolysis in body fluids. They are preventing protein adhesion, suppressing immunological response and prevent blood clot formation. They have also very low friction coefficient against blood vessel walls.
6. New polymers, new drugs and new coating technologies for coronary stents. New biodegradable polymers to be applied as a drug carrier for coronary stents should be perfectly biocompatible to prevent restenosis. New drugs are investigated which will prevent smooth muscle cells overgrowth leading to restenosis, and does not slow down endothelium cells proliferation, which is a natural healing process.
7. Cell microencapsulation techniques to be applied in regenerative medicine like bone and cartilage tissue regeneration, and also in artificial organs like artificial pancreas. These methods can also be applied in endothelium cells coatings of permanent implants.

For Companies and Research Institutions

All the time we are seeking new challenges in the area of Biomedical Engineering and looking for cooperation. Base on our experience we offer cooperation in the development of new products and technologies. We are also ready to take part in research initiatives and international research projects.

For students

We invite all students to visit our lab. If You find it interesting we can start a cooperation. We demand patience and passion to research and also basic practical knowledge of laboratory works, basic knowledge of English, and two hands to work. We offer an interesting research work in the friendly team.

Team:

Tomasz Ciach PhD Eng.
Beata Butruk-Raszeja PhD Eng.
Martyna Kucharska PhD Eng.
Magdalena Janczewska MSc Eng.
Katarzyna Kaźmierska MSc Eng.
Kamil Kopeć MSc Eng.
Piotr Kowalczyk MSc Eng.
Aleksandra Kulikowska MSc Eng.
Aleksandra Kuźmińska, MSc Eng.
Ilona Łojszczyk MSc Eng.
Aleksandra Mościcka - Studzińska MSc Eng.
Rafał Podgórski MSc Eng.
Aleksandra Poniatowska, MSc Eng.
mgr inż. Agata Stefanek
Paulina Trzaskowska MSc Eng.
Maciej Trzaskowski MSc Eng.
Iga Wasiak MSc Eng.
Michał Wojasiński MSc Eng.